Latest Episode
Resistance Training and Weight Loss: Why Muscle Matters More Than the Scale
The scale says you're down 50 pounds, but what if you feel weaker climbing stairs or getting up from a low couch? Weight loss is a big win, but what you lose along the way matters just as much as how much you lose.
Join Holly and Jim as they work through the research on muscle loss, protein, and resistance exercise. You'll hear what the studies say about whether GLP-1 medications are really to blame, whether protein alone can protect your strength, and why exercise may matter for a reason that
Recent Episodes
152
Nov. 11, 2026
Resistance Training and Weight Loss: Why Muscle Matters More Than the Scale
The scale says you're down 50 pounds, but what if you feel weaker climbing stairs or getting up from a low couch? Weight loss is a big win, but what you lose along the way matters just as much as how much you lose. Join Holly and Jim as they work through the research on muscle loss, protein, and resistance exercise. You'll hear what the studies say about whether GLP-1 medications are really to blame, whether protein alone can protect your strength, and why exercise may matter for a reason that
151
Nov. 4, 2026
Why Lifestyle Matters More Than Ever with Dr. Gary Foster
If you've ever been told lifestyle change is the key to losing weight, this episode might make you rethink the job we've been asking lifestyle to do. Now that powerful medications can produce substantial weight loss, what is healthy eating and movement really for? Join Holly and Jim as they sit down with Dr. Gary Foster, a clinical psychologist who has spent decades studying behavioral weight management. He has led academic research programs, served as chief science officer at WW (formerly Weig
150
Oct. 28, 2026
What Surprised Us Most About GLP-1 Medications and Obesity Management
What if the medications that were supposed to fix obesity turned out to be just the beginning of the story? After decades of studying weight loss, Holly and Jim thought they had seen it all. Then a new class of medications arrived and overturned some of their most basic assumptions. In this episode, each of them brings five things that genuinely surprised them about the GLP-1 era. Some are about the science, some are about what they see in patients, and some are about what these medications wer
149
Oct. 21, 2026
Why Losing Weight Might Not Make You Happier
You’ve hit your goal weight, or you’re close. So why doesn’t life feel as different as you expected? For many people, the number on the scale was never really the point. It was a stand-in for feeling confident, joining in, and finally enjoying life. Today’s weight loss medications are helping people lose weight that once felt out of reach. A large new BMJ analysis asked whether quality of life is keeping pace, and the answer may make you rethink what success means. Join Holly and Jim as they di
148
Oct. 14, 2026
What Does Your Pharmacist Want You to Know About Weight Loss Medications?
Your friend just started semaglutide. She got it online; it's "compounded," it has B12 in it, and it's only $199 a month. Sounds like a great deal, right? But what exactly is in that vial, who made it, and how much are you supposed to take? More and more people are facing these questions every day, and most of us don't know how to answer them. Join Holly and Jim as they welcome not one, not two, but three guests for the very first time: Misty Gaddis, pharmacy manager of medication compounding s
147
Oct. 7, 2026
The Weight Comes Off Easy. Now What?
New obesity medications can now produce weight loss once thought impossible without surgery. That success is forcing doctors to ask a question they never had to face before: what if a treatment doesn't know when to stop? Join Holly and Jim as they unpack six new questions these next-generation drugs have raised in obesity medicine. Using a relatable patient case, they explore the difference between losing the maximum amount of weight and losing the optimal amount, and why those two things are n
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