Latest Episode
Losing Weight on GLP-1s: Are You Moving More or Less Than Before?
If losing weight made movement easier, wouldn’t you naturally start moving more? It’s the kind of assumption that feels almost too obvious to question: shed 40 or 50 pounds, and your knees stop aching, the stairs get easier, and you’re out there living more. Holly and Jim certainly believed it. But in the age of GLP-1 medications, where rapid, substantial weight loss is now common, does this assumption still hold up?
In this episode, Holly and Jim put that belief to the test with real data. Div
Recent Episodes
146
Sept. 30, 2026
Losing Weight on GLP-1s: Are You Moving More or Less Than Before?
If losing weight made movement easier, wouldn’t you naturally start moving more? It’s the kind of assumption that feels almost too obvious to question: shed 40 or 50 pounds, and your knees stop aching, the stairs get easier, and you’re out there living more. Holly and Jim certainly believed it. But in the age of GLP-1 medications, where rapid, substantial weight loss is now common, does this assumption still hold up? In this episode, Holly and Jim put that belief to the test with real data. Div
145
Sept. 23, 2026
Are You Eating Healthier While Eating Less on GLP-1 Medications?
Everyone knows GLP-1 medications help people eat less. But does eating less actually mean eating better? It’s a question the weight loss field never really had to ask before, and the answer might surprise you. Join Holly and Jim as they dig into three GLP-1 studies looking at what people are actually eating. You’ll hear the real numbers behind diet quality, protein intake, and nutrient gaps on these medications, plus what it means for anyone currently taking (or considering) a GLP-1. Holly and
144
Sept. 16, 2026
Pop Quiz: What Do You Really Know About Keeping Weight Off?
Think you know what it takes to keep weight off? Most people can tell you how to lose weight, but ask them what actually predicts keeping it off, and the answers get shaky fast. That’s a problem, because losing weight and maintaining weight loss are two completely different biological and behavioral games, and confusing the two is one of the biggest reasons people yo-yo. In this episode, Holly and Jim put their listeners to the test literally. They’ve built a 20-question pop quiz covering every
143
Sept. 9, 2026
What Should We Eat? Evolution, Diet, and Eating Well with Daniel Lieberman
What did humans actually evolve to eat? With paleo, keto, vegan, Mediterranean, and a thousand other diets all claiming to be "the one," it's no wonder people feel whiplashed every time they walk into a grocery store. But what if the answer isn't found in the latest diet book, but in millions of years of human evolution? Join Holly and Jim as they welcome back Harvard evolutionary biologist Dan Lieberman for a second appearance on the show. This time, Dan isn't talking exercise. He's talking fo
142
Sept. 2, 2026
Ten Key Decisions That Shape Your Weight Loss Success
Most people trying to lose weight obsess over the what: what diet, what medication, what workout plan. But according to Holly and Jim, the real key to long-term success isn't found in any of those choices. It's found in a set of decisions most people never even realize they're making. In this episode, Holly and Jim count down the 10 decisions that determine whether a weight loss journey actually sticks. Some are questions you'd expect. Others might catch you completely off guard, including the
141
Aug. 26, 2026
Triple Agonists: Revolutionizing Weight Loss or Too Much of a Good Thing?
For years, the ceiling on medical weight loss was 15%, maybe 20% if you were lucky. Now a new triple-target medication is posting average results that flirt with 30% body weight loss in clinical trials, numbers once reserved for the operating room. Holly and Jim sat down to unpack what's driving these results, and found themselves asking a question neither expected to ask in their careers: how much weight loss is actually too much? Retatrutide, the drug at the center of this episode, adds a thi
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